The present research study was to develop Pulsatile release tablet formulation of Lornoxicam as chronopharmaceutical drug delivery system (ChrDDS) for treatment of rheumatoid arthritis, which are influenced by circadian rhythm. Arthritis pain mainly takes place in the early morning. Pulsatile drug delivery system is capable of delivering drug when and where it required most. Time-delayed formulation, designed to release drug after a lag time, are intended for oral chronotherapy. The basic design consists of a core tablet coated by various polymers to avoid premature drug release in upper GIT. FTIR study was carried out to study drug excipient compatibility. The core tablets were prepared by using different super disintegrants like Crospovidone, sodium starch glycolate and cross carmelose sodium. . The prepared core tablets were evaluated parameter like Precompression and post compression parameters. The optimize batches was selected for core tablet because it showed lesser disintegration time than other formulations and it was used for compression coated tablet preparation. The pulsatile release compression coated tablets were prepared by using different polymers HPMC K100M, Ethyl cellulose, L-HPC and evaluated parameters like hardness, weight variation, friability, dissolution study and lag time study. The optimized pulsatile release tablets consisting of %cumulative drug release and lag time. Hence it can be concluded that combination polymer like HPMC K 100M and ethyl cellulose could be successfully used for preparation of pulsatile release dosage form.
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